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Heteromorphic and azapidan compounds as Btk active inhibitors
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
CRAWFORD, JAMES JOHN,ORTWINE, DANIEL FRED,WEI, BINQING,YOUNG, WENDY B.
申请号:
PE2014000638
公开号:
PE20141586A1
申请日:
2012.11.02
申请国别(地区):
PE
年份:
2014
代理人:
摘要:
It refers to formula compound (I),X1 is CR1 or N; X2 is CR2 or N; X3 is CR3 or N; x1, X2 and X3 are n; R1, R2 and R3 are independent h, F, cl-nh2.-OCH3 - Oh, c1-c3-nhch3, among others, R4 is h, F, Cl, cn-ch2oh, among others, R5 is arilo c6-c20, heterocyclic c2-c20, C1-C20 heterogeneous, among others, R6 is h, CH3, ch2ch3, oh, among others, R7 is a,B,Among other things, wavy lines represent joint sites; Y1 and Y2 are independent of CH and N, and also refer to a drug synthesis. These compounds can be used to treat cancer, cardiovascular disease, virus infection, nervous system disorders.SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: X1 ES CR1 O N; X2 ES CR2 O N; X3 ES CR3 O N; DONDE UNO O DOS DE X1, X2 Y X3 SON N; R1, R2 Y R3 SON INDEPENDIENTEMENTE H, F, Cl -NH2-, -OCH3, -OH, ALQUILO C1-C3, -NHCH3, ENTRE OTROS; R4 ES H, F, Cl, CN, -CH2OH, ENTRE OTROS; R5 ES ARILO C6-C20, HETEROCICLILO C2-C20, HETEROARILO C1-C20, ENTRE OTROS; R6 ES H, -CH3, -CH2CH3, -OH, ENTRE OTROS; R7 ES a), b), ENTRE OTROS, DONDE LA LINEA ONDULADA INDICA EL SITIO DE UNION; Y1 E Y2 SON INDEPENDIENTEMENTE CH Y N. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE CANCER, ENFERMEDAD CARDIOVASCULAR, INFECCION VIRAL, TRASTORNOS NEUROLOGICOS
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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