METHODES DE CRIBLAGE VISANT A TROUVER DES MEDICAMENTS CANDIDATS QUI PERTURBENT L'INTERACTION ENTRE MIF ET JAB1, LE COMPLEXE MIF ET JAB1, ANTICORPS ET LEUR UTILISATION

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专利权人:

FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

发明人:

BRUNNER, HERWIG,BERNHAGEN, JURGEN,KLEEMANN, ROBERT,MISCHKE, RALF,KAPURNIOTU, AFRODITI

申请号：

CA2391392

公开号：

CA2391392C

申请日:

2000.11.02

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

A method for screening candidate drugs is disclosed. The method testswhether the candidate drug disrupts an interaction between MIF(macrophage migration inhibitory factor) and Jab1 (c-Jun activation domainbinding protein). The method comprises the step of detecting in a MIF andJab1 system, in the absence of the candidate drug, an interaction betweenMIF and Jabi and comparing the detected interaction to an interactiondetected in the MIF and Jabi system in the presence of the candidate drug.The method is not practiced on the human body.

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