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COMPOSITIONS AND METHODS USING PEPTIDES CONTAINING BASIC AMINO ACIDS AND PROTEASES
专利权人:
КОЛЕЙГТ-ПАЛМОЛИВ КОМПАНИ (US)
发明人:
РОБИНСОН Ричард (US),САЛЛИВАН Ричард (US)
申请号:
RU2010137274/15
公开号:
RU2010137274A
申请日:
2009.02.06
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. An oral care composition that contains (i) an effective amount of a peptide or a mixture of peptides enriched in basic amino acids, and (ii) a protease that cleaves said peptide and releases basic amino acids in the oral cavity, the composition is intended for use by a consumer in the oral cavity. ! 2. The composition according to claim 1, where the length of the peptide is from about 5 to 500 amino acids. ! 3. The composition according to claim 1 or 2, further comprising one or more of:! a. source of calcium ion,! b. source of phosphate ion,! with. source of potassium ion,! d. fluoride source! e. Moisturizer based on polyhydric alcohol,! f. protease inhibitor! and their combinations. ! 4. The composition according to claim 1, where the basic amino acids are selected from the group comprising arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminopropionic acid, their salts and / or combinations. ! 5. The composition according to claim 1, where more than about 50% of the amino acids in the peptide are basic amino acids. ! 6. The composition according to claim 1, containing a mixture of peptides obtained by partial hydrolysis or partial cleavage of the protein and enrichment of the obtained fragments with peptides containing basic amino acids. ! 7. The composition according to claim 1, where the peptide provides a basic pH in an aqueous solution. ! 8. The composition according to claim 1, where the peptide is enriched in arginine. ! 9. The composition according to claim 1, where the basic amino acid is present in an amount of about 0.1 to 20% with respect to the total weight of the composition, and if the composition is used in the oral cavity, the mass of the basic amino acid is calculated on the free base. ! 10. Composition p1. Композиция для ухода за полостью рта, которая содержит (i) эффективное количество пептида или смеси пептидов, обогащенных основными аминокислотами, и (ii) протеазу, которая расщепляет указанный пептид и
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