РОБЕРТ БОШ ГЕЗЕЛЬШАФТ ФЮР МЕДИЦИНИШЕ ФОРШУНГ МБХ (DE)
发明人:
ВЕКАМП Ян (DE),ШРЁДЕР Бьёрн (DE),ШТАНГЕ Эдуард (DE)
申请号：
RU2014140231
公开号：
RU2014140231A
申请日:
2013.03.07
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The peptide or its derivative, which / which has antimicrobial activity and has a C-terminus and an N-terminus and consists of at least eight and at least 12 consecutive amino acids, where the peptide has the sequence represented by the following formula I: in which Ter denotes the free N-terminal amino group of the N-terminal amino acid X or a modified N-terminal amino group； X, Chi, Xi are the same or different, and are each selected independently from each other from amino acids with basic side chains In particular, they are preferably selected from the following amino acids: arginine, lysine, 6-hydroxylisine, homoarginine, 2,4-diaminobutyric acid, β-homoarginine, D-arginine, arginine, 2-amino-3-guanidinopropionic acid, nitroarginine, n-methylarginine , ε-n-methyllysine, allo-hydroxylisine, 2,3-diaminopropionic acid, 2,2′-diaminopimelic acid, ornithine, sim-dimethylarginine, asym-dimethylarginine； Vi appear the same or different, and they are selected in each case independently from a friend from amino acids having an aliphatic or main side chain, and is preferably selected from alanine or glycine； Z and Z either are cysteine, or they are cysteine and alanine； and Ter is the free C-terminal carboxyl group of the C-terminal amino acid Healy is a modified C-terminal carboxyl group. 2. The peptide according to claim 1, characterized in that it consists of eight consecutive amino acids and has the sequence of formula I.3. The peptide or its derivative according to claim 1 or 2, characterized in that the peptide is selected from peptides having SEQ ID NO: 1-6, or their derivatives, where derivatives are obtained1. Пептид или его производное, который/которое обладает антимикробной активностью и имеет С-конец и N-конец и состоит как минимум из восьми и как максимум из 12 последовательно расположенных аминокислот, где пептид имеет последовательность, представленную в следующей формуле I:в которой Terобозначает свободную N-концевую аминогруппу N-концевой аминокислоты X
