Xiangming Fang,Ruyi Lei,Qixing Chen,Jinchao Hou,Baoli Cheng,Yue Jin
申请号：
US15459467
公开号：
US20180016308A1
申请日:
2017.03.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A human α-defensin 5 variant is obtained by adding amino acid residues at C-terminal of α-defensin 5 and then being modified to link an aliphatic acid. At least one of the added amino acid residues has a free amino group, and the free amino group is modified to link an aliphatic acid with 8-24 carbon atoms. The variant is used in manufacture of an antibacterial agent and an immunomodulatory agent. Antibacterial activity is significantly enhanced by extending and modifying the C-terminal of HD-5； in particular, salt tolerance is significantly improved by extending the C-terminal of HD-5 with Lys and then being modified with myristic acid, thereby breaking the restriction of salt-sensibility of conventional antimicrobial peptides. The variant can significantly promote release of inflammatory factors from macrophages and thus can be applied in manufacture of immunomodulatory agent.
