Grosveld Franklin Gerardus,Janssens Richard Wilhelm,Van Haperen Marinus Johannes,Craig Roger Kingdon,De Boer Ernie
申请号：
US201414211130
公开号：
US9980470(B2)
申请日:
2014.03.14
申请国别(地区):
美国
年份:
2018
代理人:
Saul Ewing Arnstein & Lehr LLP
摘要：
A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
