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专利权人:
ABBVIE DEUTSCHLAND GMBH & CO. KG
发明人:
ANDREAS HAUPT
申请号:
MX2015005093
公开号:
MX2015005093A
申请日:
2013.10.21
申请国别(地区):
MX
年份:
2015
代理人:
摘要:
The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of the formula (I) as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor. In formula (I), the variables have the following meanings: m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2, R1 is hydrogen or C1-C3-alkyl, R2 is selected from the group consisting of hydrogen, and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, and R5 is an oxygen containing radical such as C1-C2-alkoxy-C1-C4- alkyl, fluorinated C1-C2-alkoxy-C1-C4- alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, C3-C5 cycloalkoxy-C1-C4-alkyl and fluorinated C3-C5 cycloalkoxy-C1-C4-alkyl.Nuevos compuestos de acilaminocicloalquilo de fórmula I que son como se describe en la presente, sus sales y sus N óxidos, que presentan propiedades terapéuticas valiosas y que resultan particularmente apropiados para tratar aquellas enfermedades que responden a la modulación del receptor de dopamina D3. (ver Fórmula) En la fórmula I, las variables tienen los siguientes significados: m es 1 ó 2, n es 1 ó 2, A se selecciona del grupo que consiste en CH2, CH2CH2, CHFCH2 y CF2CH2, R1 es hidrógeno o un alquilo C1-C3, R2 se selecciona del grupo que consiste en hidrógeno y flúor, R3a se selecciona del grupo que consiste en hidrógeno y metilo, R3b se selecciona del grupo que consiste en hidrógeno y metilo, R4 es un alquilo C4-C6 ramificado o un alquilo C4-C6 ramificado fluorado y R5 es un radical que contiene oxígeno, tal como un alcoxi C1-C2-alqu
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