DERIVES DE 1,3,8-TRISUBSTITUE-1,3,8-TRIAZA-SPIRO[4.5]DECAN-4-ONE UTILISES COMME LIGANDS DU RECEPTEUR ORL-I DANS LE TRAITEMENT DE L'ANXIETE ET DE LA DEPRESSION
BIGNAN, GILLES C.,HLASTA, DENNIS J.,RYAN, RICHARD R.
申请号：
CA2683598
公开号：
CA2683598C
申请日:
2008.02.14
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention is directed to novel 1.3.8-trisubstituted-1.3,8-triaza-spiro[4:5]decan-4-one derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. R3 is selected from the group consisting of R0 is selected from the group consisting of -CCH, hydroxy, -N3, -O-C(0)-C1-4 alkyl, -O-SO2-C1-4 alkyl, -O-(2- tetrahydropyranyl)； wherein R1 is 1-ace.pi.a.rho.hthenyl； R2 is 4-fluorophenyl； A1 is selected from the group consisting of -CH2-,-CH2CH2-,-CH2CH2- and -CH2CH2CH2CH2
