Malcolm Scott;Peter J. Connolly;Tina Morgan Ross;Kathleen Battista;Gilles Bignan;Michael Orsini;Steven A. Middleton;Allen B. Reitz
发明人:
Kathleen Battista,Gilles Bignan,Peter J. Connolly,Allen B. Reitz,Tina Morgan Ross,Malcolm Scott,Steven A. Middleton,Michael Orsini
申请号：
US12327437
公开号：
US08778956B2
申请日:
2008.12.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formulawherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain, migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.
