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Acadesin derivatives, products and compositions that comprise them, their therapeutic uses and their synthesis procedures
专利权人:
UNIVERSITÉ NICE SOPHIA ANTIPOLIS;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
发明人:
BENHIDA, RACHID,AUBERGER, PATRICK,MALNUIT, VINCENT,DRIOWYA, MOHSINE,PUISSANT, ALEXANDRE,ROBERT, GUILLAUME
申请号:
ES12722749
公开号:
ES2544542T3
申请日:
2012.04.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compounds of the general formula: ** Formula ** in which: - R1 is selected from a · cyclic pentose group in a furyic form with free OH groups or possibly substituted with one or more mono-, bi- or triphosphate, acetyl , isopropylidene, benzoyl or paratoluoyl, · a hexose group in pyranic form with free OH groups or possibly substituted with one or more mono-, bi- or triphosphate or acetyl groups, · a naphthyl group, optionally substituted with one or several alkyl groups or substituted amino having 1 to 4 carbon atoms, · a benzyl group optionally substituted with one or more alkyl or substituted amino groups having 1 to 4 carbon atoms, · phenyl, biphenyl, heteroaryl groups; - R2 is selected from · an amide group -CONH2, -CONHMe, -CONHEt, -CON (Me) 2, -CON (Et) 2, · an acid or ester group -CO2H, CO2Me, CO2Et, a cyano group or amidine -CN, -C (NH2) NH, -C (NHMe) NH, -C (NHEt) NH, · a phenyl group optionally substituted by a halogen selected from CI, Br, I and F, · a thiophene group, · A linear or branched carbon chain having 3 to 10 carbon atoms, or · a methoxynaphthalene group; and - R3 is selected from: · a halogen group, · a furan or -CO-furan group, · a thiophene or -CO-thiophene or -C≡C-thiophene group, · a toluoyl group, · an acetylene group, · A -CO- (CH2) n-CH3 group, with n between 2 and 9, · a phenyl or -C≡C-phenyl group, optionally substituted with a halogen, · a -C≡C-CO2Me group, - C≡C-CO2Et, -C≡C-CONH2, · a group -C≡C- (CH2) 6CH3, or · a group -C>; = C-2-methoxynaphthalene; its racemic, enantiomers, diastereoisomers and mixtures thereof, its tautomers and pharmaceutically acceptable salts, for use as a medicine.Compuestos de fórmula general:**Fórmula** en la que: - R1 se selecciona de entre · un grupo pentosa cíclica en forma furánica con los grupos OH libres o eventualmente sustituidos con uno o varios grupos mono-, bi- o trifosfato, acetilo, isopropilideno, benzoilo o paratoluoilo, · un grupo hexosa en forma piránica con los grupos OH libres o eventual
来源网站:
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