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3-Pyrrolo [b] cyclohexylene-2-dihydroindolinone derivatives and uses thereof
专利权人:
JIANGSU SIMCERE PHARMACEUTICAL R&D CO.; LTD.
发明人:
TANG, FENG,SHEN, HAN,JIN, QIU,DING, LEI,YANG, JIE,YIN, XIAOJIN,LU, SHIYUE
申请号:
ES07817351
公开号:
ES2383084T3
申请日:
2007.12.03
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 is selected from the group consisting of hydrogen, halo, alkyl, cycloalkyl, heteroalicyclic, hydroxy, alkoxy, -C (O) R7, - NR8R9, - (CH2) nR10 and -C (O) NR11R12; R2 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, nitro, cyano, -NR8R9, -NR8C (O) R9, -C (O) R7, -C (O) NR11R1 ; -S (O) 2NR8R9 and -SO2R13R3 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, hydroxy, alkoxy, -C (O) R7, - NR8R9, -NR8S (O) 2R9, -S (O ) 2NR8R9, -NR8C (O) R9, -NR8C (O) OR9 and -SO2R13; R4 is selected from the group consisting of hydrogen, halo, alkyl, hydroxy, alkoxy and -NR8R9; R5 is selected from the group consisting of hydrogen, alkyl and -C (O) R14; R6 is selected from the group consisting of hydroxy, alkoxy, aryloxy, -N (R15) (CH2) rR16, -NR8R9 and -N (R17) -CH (R18) - CR19 (OH) -CH (R20) Z; R7 is selected from the group consisting of hydrogen, hydroxy, alkoxy and aryloxy; each of R8 and R9 is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl and heteroaryl; or R8 and R9 together with the atoms to which they are attached can form a heterocyclic ring; R10 is selected from the group consisting of hydroxy, -C (O) R7, -NR8R9 and -C (O) NR8R9; each of R11 and R12 is independently selected from the group consisting of hydrogen, alkyl and aryl; or R11 and R12 together with the nitrogen atom to which they are attached can form a heterocyclic ring; R13 is selected from the group consisting of alkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; R14 is selected from the group consisting of hydroxy, alkoxy, aryloxy and -NR8R9; R15 is selected from the group consisting of hydrogen and alkyl;Un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable del mismo: en la que: R1 se selecciona entre el grupo que consiste en hidrógeno, halo, alquilo, cicloalquilo, heteroalicíclico, hidroxi, alcoxi,
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