BLOMGREN, Peter A.,CURRIE, Kevin S.,KROPF, Jeffrey E.,LEE, Seung H.,DARROW, James W.,MITCHELL, Scott A.,XU, Jianjun,SCHMITT, Aaron C.
申请号：
ES07842263
公开号：
ES2576478T3
申请日:
2007.09.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound selected from the compounds of formula 1: ** Formula ** and pharmaceutically acceptable non-covalent salts, solvates, chelates and complexes, and mixtures thereof, wherein R is selected from aryl, heteroaryl and ** Formula * * in which: aryl comprises carbocyclic aromatic rings of 5 and 6 elements, bicyclic ring systems in which at least one ring is carbocyclic and aromatic； and tricyclic ring systems in which at least one ring is carbocyclic and aromatic； and wherein aryl includes carbocyclic aromatic rings of 5 and 6 elements fused with a heterocycloalkyl ring of 5 to 7 elements containing 1 or more heteroatoms selected from N, O and S； heteroaryl comprises aromatic monocyclic rings of 5 to 7 elements containing one or more heteroatoms selected from N, O and S, the remaining ring atoms being carbon； and bicyclic heterocycloalkyl rings containing one or more heteroatoms selected from N, O and S, the remaining ring atoms being carbon and in which at least one heteroatom is present in an aromatic ring； and wherein heteroaryl includes a 5-7 element heterocycloalkyl aromatic ring fused with a 5 to 7 element cycloalkyl ring； R5 is selected from hydrogen, hydroxy, alkyl groups having one to four carbons, sulfonyl, amino and alkoxy groups having four carbons, alkyl groups having four carbons substituted with one or more halos, alkoxy groups having four carbons substituted with one or more halos, alkyl groups having four carbons substituted with hydroxy, heterocycloalkyl and heteroaryl； and X is selected from N and CH； R4 is selected from hydrogen, alkyl groups having four carbons, alkoxy groups with one to four carbons, halo and hydroxy； R21 and R22 are independently selected from hydrogen and alkyl groups having four carbons； R16 is selected from hydrogen, cyano, cycloalkyl and alkyl groups having four carbons； and alkyl groups having four carbons substituted with a group selected from alkoxy, amino and acyl； L is selected from C0-C4 alkylene, -O-C0-C4 alkylene,
