The present invention discloses formula (I) compound, in which: two Ge Xu Line indicate two singly-bounds or two double bonds； Q are as follows: or R1 is F, Cl, CN or CH3； R2 is Cl or CH3； R3 is C (CH3) 2OH or CH2CH2OH； Ra is H or CH3； Each Rb independently is F, Cl, CH3 and/or OCH3； And n is 0,1 or 2. Invention additionally discloses use the compound as the method for the inhibitor of bruton's tyrosine kinase (Btk), and the pharmaceutical composition comprising the compound. The treatment of these compound whats prevents disease in various therapy fields or illness (such as autoimmune disease and vascular diseases) or slows down its progress.本發明公開式(I)化合物，其中：兩個虛綫表示兩個單鍵或兩個雙鍵；Q爲：或R1爲F、Cl、CN或CH3；R2爲Cl或CH3；R3爲C(CH3)2OH或CH2CH2OH；Ra爲H或CH3；各Rb獨立地爲F、Cl、CH3和／或OCH3；且n爲0、1或2。本發明還公開使用所述化合物作爲布魯頓酪氨酸激酶(Btk)的抑制劑的方法，及包含所述化合物的藥物組合物。這些化合物用於治療、預防各種治療領域中的疾病或病症（諸如自身免疫疾病及血管疾病）或減緩其進展。
