Liming Wang;Evelyn G. Corpuz;Ken Chow;Wha-Bin Im;Wenkiu K. Fang
发明人:
Wenkiu K. Fang,Liming Wang,Evelyn G. Corpuz,Ken Chow,Wha-Bin Im
申请号：
US13498499
公开号：
US20120208840A1
申请日:
2010.09.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these compounds selected from the group consisting of wherein A, B, C, D, X, Y, Z and R3 are defined in the specification. Said compounds are useful for treating a disease or condition of a mammal selected from the group consisting of ocular diseases； systemic vascular barrier related diseases； allergies and other inflammatory diseases； cardiac diseases or conditions； fibrosis； pain and wounds.
