PETEREIT, HANS-ULRICH,MEIER, CHRISTIAN,GRYCZKE, ANDREAS
申请号：
CA2512738
公开号：
CA2512738C
申请日:
2003.11.21
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to a method for producing an oral form of administrationwhich decomposes immediately and releases active ingredients in the mouth.According to said method, (a) an anionic pharmaceutical active ingredient isintensively mixed with (b) a copolymer consisting of radically polymerised C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylatemonomers containing functional tertiary amino groups, and (c) between 5 and 50wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass；the mixture is solidified and ground to form a powder containing activeingredients having an average particle size of 200 ~m or less； and the powderis encapsulated in a water-soluble matrix consisting of pharmaceuticallystandard adjuvants, on the condition that no more than 3 wt. %, in relation tothe copolymer, of emulsifiers with an HLB value of at least 14 must becontained therein. The invention also relates to the powder containing activeingredients and the uses of the same.
