FORME GALENIQUE MULTIPARTICULAIRE RENFERMANT DES PRINCIPES ACTIFS CONTENANT UN ACIDE NUCLEIQUE A FORMULATION MUCOADHESIVE, AINSI QUE PROCEDE POUR PRODUIRE CETTE FORME GALENIQUE
LIZIO, ROSARIO,PETEREIT, HANS-ULRICH,TRUPTI, DAVE,GOTTSCHALK, MICHAEL
申请号：
CA2586597
公开号：
CA2586597C
申请日:
2005.11.05
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to an oral multiparticulate pharmaceutical formcomprising pellets having a size in the range from 50 to 2500 µm, whichare essentially composed of a) an inner matrix layer comprisingnanoparticles which comprise a nucleic acid active ingredient, and isincorporated into a matrix of a polymer having a mucoadhesive effect,and b) an outer film coating consisting essentially of an anionic polymeror copolymer which may optionally be formulated with pharmaceuticallyusual excipients, especially plasticizers. The invention providespharmaceutical forms which can be administered orally for nucleic acidactive ingredients.
