MULTIPARTICULATE FORM OF ADMINISTRATION, COMPRISING NUCLEIC ACID-CONTAINING MUCOADHESIVE ACTIVE INGREDIENTS, AND METHOD FOR PRODUCING THE SAID FORM OF ADMINISTRATION
LIZIO RISARIO,PETEREIT HANS-ULRICH,DAVE TRUPTI,GOTTSCHALK MICHAEL
申请号：
IN2517/CHENP/2007
公开号：
IN260690B
申请日:
2007.06.12
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 μg(m)m which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients.
