FORME GALENIQUE MULTIPARTICULAIRE RENFERMANT DES PRINCIPES ACTIFS CONTENANT UN ACIDE NUCLEIQUE A FORMULATION MUCOADHESIVE, AINSI QUE PROCEDE POUR PRODUIRE CETTE FORME GALENIQUE
LIZIO, ROSARIO,PETEREIT, HANS-ULRICH,TRUPTI, DAVE,GOTTSCHALK, MICHAEL
申请号：
EP05807707.4
公开号：
EP1824457B1
申请日:
2005.11.05
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients.
