Večdelna oblika administracije, ki vsebuje mukoadhezivne aktivne učinkovine, ki vsebujejo nukleinsko kislino in postopek za izdelavo omenjene oblike administracije
LIZIO Rosario,PETEREIT Hans-Ulrich,TRUPTI Dave,GOTTSCHALK Michael
申请号：
SI200532058
公开号：
SI1824457T1
申请日:
2005.11.05
申请国别(地区):
SI
年份:
2016
代理人:
摘要：
The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients.
