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Method For Producing An Oral Pharmaceutical Form With Immediate Disintegration And Active Ingredient Release
专利权人:
Andreas GRYCZKE;Hans-Ulrich PETEREIT;Christian MEIER
发明人:
Hans-Ulrich PETEREIT,Christian MEIER,Andreas GRYCZKE
申请号:
US13677740
公开号:
US20130071475A1
申请日:
2012.11.15
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass; the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 μm or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.
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