PETEREIT HANS-ULRICH,PETEREIT Hans-Ulrich,MEIER CHRISTIAN,MEIER Christian,GRYCZKE ANDREAS,GRYCZKE Andreas
申请号：
SI200332408
公开号：
SI1587497T1
申请日:
2003.11.21
申请国别(地区):
SI
年份:
2015
代理人:
摘要：
The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 &mum or less and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.
