您的位置: 首页 > 农业专利 > 详情页

DERIVES DE PYRAZINO[2,1-A]ISOQUINOLINE POUR LE TRAITEMENT DES TROUBLES DU SNC
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
CECERE, GIUSEPPE,GALLEY, GUIDO,NORCROSS, ROGER,PATINY-ADAM, ANGELIQUE,PFLIEGER, PHILIPPE
申请号:
CA2953040
公开号:
CA2953040A1
申请日:
2015.08.24
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present invention relates to a compound of formula (I) wherein R1/R2 are independently from each other hydrogen or halogen; L is a bond, -NH-, -C(O)NH-, -NHC(O)- or NHC(O)NH-; R is hydrogen, lower alkyl, cycloalkyl, benzyl, phenyl or a five or six membered heteroaryl group, wherein phenyl and the heteroaryl groups are optionally substituted by one or two substituents, selected from halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cycloalkyl or di-lower alkyl amino or R is halogen if L is a bond. or to a pharmaceutically suitable acid addition salt thereof, to all racemic mixtures, all their corresponding enantiomers and/or optical isomers. The compounds of formulas (I) have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1 and may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充