ANJA LIMBERG,BAVANI G. SHANKAR,CLAUS RIEMER,DANIELA BRUNNER,ERIC PRINSSEN,JESSICA MALBERG,SABINE KOLCZEWSKI,THEODOR STOLL
申请号：
BR112015005186
公开号：
BR112015005186A2
申请日:
2013.09.10
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
patent summary: "2-oxo-2,3-dihydroindoles for treatment of snc disorders". the present invention relates to 2-oxo-2,3-dihydroindoles of formula i wherein it is phenyl or a heteroaryl group selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl or pyrazolyl； is phenyl or pyridinyl, wherein the n atom in the pyridinyl group may be in all free positions； R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or halogen； n is 1 or 2； if n is 2, r1 may or may not be equal； R 2 / R 2 'are independently lower alkyl, or form together with the carbon atom to which they are attached a C 3-6 cycloalkyl ring； R3 is lower alkyl, C3-6 cycloalkyl, ch2 -C3-6 cycloalkyl, C3-6 cycloalkyl wherein one carbon atom in the ring is substituted by -o-, cycloalkyl (ch2) 3-o-c3-6, lower alkyl substituted by hydroxy, lower alkyl substituted by halogen, cycloalkyl (ch2) 3-s (o) 2-c3-6 or lower alkyl (ch2) 2-s (o) 2； R4 is hydrogen, halogen or lower alkyl； m is 1 or 2； if m is 2, r4 may or may not be equal； as well as with pharmaceutically acceptable salts thereof, with a racemic mixture, or with their enantiomer and / or optical isomer and / or corresponding stereoisomer thereof.resumo patente de invenção: “2-oxo-2,3-di-hidro-indóis para tratamento de distúrbios do snc”. a presente invenção refere-se a 2-oxo-2,3-di-hidro-indóis de fórmula geral i em que é fenila ou um grupo heteroarila, selecionado a partir de piridinila, pirimidinila, imidazolila, isoxazolila ou pirazolila； é fenila ou piridinila, em que o átomo de n no grupo piridinila pode estar em todas as posições livres； r1 é hidrogênio, alquila inferior, alquila inferior substituída por halogênio, alcóxi inferior ou halogênio； n é 1 ou 2； se n for 2, r1 pode ser igual ou não； r2/r2’ são independentemente alquila inferior, ou formam juntamente com o átomo de carbono ao qual esses são ligados um anel cicloalquila c3-6； r3 é alquila inferior, cicloalquila c3-6, cicloalquila ch2-c3-6, cicloalquila c3-6 em que um
