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LIVE-ATTENUATED VIRUS AND METHODS OF PRODUCTION AND USE
专利权人:
The University of Hong Kong
发明人:
Lit Man Poon,Lok Yan Fan
申请号:
US15174348
公开号:
US20160354460A1
申请日:
2016.06.06
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Presented herein are live-attenuated viruses and methods of generating thereof from a parental virus through a plurality of nucleotide substitutions in the viral genome. The nucleotide substitutions result in a change in codon usage bias within codons of one or more protein encoding sequences and no change in amino acid sequences of the proteins. The live-attenuated viruses display unaltered replication in avian hosts for propagation, but attenuated replication in mammalian hosts, when compared to the replication of the parental virus. The live-attenuated viruses in a form of improved vaccines can be used to elicit protective immune responses.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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