CYCLOPROPYL-FUSED PYRROLIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS
ROBL, JEFFREY A.,SULSKY, RICHARD B.,AUGERI, DAVID J.,MAGNIN, DAVID R.,HAMANN, LAWRENCE G.,BETEBENNER, DAVID A.
申请号：
HU0302792
公开号：
HU228110B1
申请日:
2001.03.05
申请国别(地区):
HU
年份:
2012
代理人:
摘要：
Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or 1 and y is 0 or 1 (provided that x = 1 when y = 0 and x = 0 when y = 1)； n is 0 or 1； X is H； and wherein R 1 , R 2 , R 3 and R 4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity and/or other therapeutic agent.
