Novel crystalline forms of a dipeptidyl peptidase-IV inhibitor

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专利权人:

Merck Sharp & Dohme Corp.;Merck Sharpe & Dohme Ltd.

发明人:

Arroyo, Itzia,Krueger, Davida,Chen, Ping,Moment, Aaron,Biftu, Tesfaye,Sheen, Faye,Zhang, Yanfeng

申请号：

AU2012275637

公开号：

AU2012275637B2

申请日:

2012.06.25

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

Novel crystalline forms of (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine are potent inhibitors of dipeptidyl peptidase-IV and are useful for the treatment of non-insulin dependent (Type 2) diabetes mellitus. The invention also relates to pharmaceutical compositions containing these novel forms, processes to prepare these forms and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes.

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