Jeffrey A. Robl;David J. Augeri;Richard B. Sulsky;David A. Betebenner;David R. Magnin;Lawrence G. Hamann
发明人:
Jeffrey A. Robl,Richard B. Sulsky,David J. Augeri,David R. Magnin,Lawrence G. Hamann,David A. Betebenner
申请号：
US13308658
公开号：
USRE044186E1
申请日:
2011.12.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formulawherex is 0 or 1 and y is 0 or 1 (provided thatx=1 when y=0 and x=0 when y=1)；n is 0 or 1； X is H or CN；and wherein R1, R2, R3 and R4 are as described herein.A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor *or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent.
