DETECTION OF ARGININE METHYLATION OF EGFR FOR PREDICTION OF RESISTANCE TO THERAPY

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专利权人:

THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS

发明人:

Mien-Chie HUNG,Hsin-Wei LIAO,Jung-Mao HSU

申请号：

US15036797

公开号：

US20160279240A1

申请日:

2014.11.19

申请国别(地区):

US

年份:

2016

代理人:

摘要：

This invention provides biomarkers (e.g., methylation of R198 or R200 of EGFR or the presence of an arginine at position 497 of EGFR) for the prediction of resistance to cetuximab therapy. This invention also provides methods for the selection of patients for combination therapy with cetuximab and PRMT inhibitors.

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中国工程科技知识中心

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http://www.ckcest.cn/home/