Microbial approach for the production of 5-hydroxytryptophan

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专利权人:

发明人:

Yajun Yan,Yuheng Lin

申请号：

US15310040

公开号：

US10023889B2

申请日:

2015.05.14

申请国别(地区):

US

年份:

2018

代理人:

摘要：

5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.

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中国工程科技知识中心

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http://www.ckcest.cn/home/