Arleen Rifkind,Silvia Diani-Moore,J. David Warren,Erin Hall,Yuliang Ma
申请号：
US13379327
公开号：
US20120283282A1
申请日:
2010.06.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
We have found that exposure of an aqueous tryptophan solution to window sunlight results in the production of multiple tryptophan photoproducts that have the capability of activating the aryl hydrocarbon receptor and increasing the production of AhR target genes and proteins in hepatocytes. We have isolated three of those photoproducts not previously identified as AhR activators, their chemical identification and synthesis and the demonstration that all three have biologic activities as novel AhR activators. Further, one of the three is a completely novel, not previously described, chemical compound.
