BLANCHETOT CHRISTOPHE,DE HAARD JOHANNES,DREIER TORSTEN,DE JONGE NATALIE,VAN DER WONING SEBASTIAN PAUL,ONGENAE NICOLAS
申请号：
NZ70137013
公开号：
NZ701370A
申请日:
2013.05.23
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The present invention provides binding molecules (e.g., antibodies or antigen binding fragments thereof) that specifically bind to and inhibit the biological activity of IL-6 (e.g., human, mouse and non-human primate IL-6) with high affinity and low immunogenicity. In a preferred embodiment, the antibodies or antigen binding fragments of the invention bind to IL-6 and inhibit its binding to an IL-6 receptor. Such antibodies or antigen binding fragments can be used for treating IL-6-associated diseases or disorders (e.g., inflammatory disease and cancer).
