CHEKAL, BRIAN PATRICK,查可 布莱恩,查可 布萊恩,IDE, NATHAN D.,艾德 南森,艾德 南森
申请号：
TW103105287
公开号：
TWI633103B
申请日:
2014.02.18
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
This invention relates to the crystalline free base of acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one having improved properties, to pharmaceutical compositions and dosage forms comprising the free base, and to methods for making and using such compounds, compositions and dosage forms in the treatment of cell proliferative diseases, such as cancer.本發明關於具有經改善性質之乙醯基-8-環戊基-5-甲基-2-(5-哌-1-基-吡啶-2-基胺基)-8H-吡啶並[2,3-d]嘧啶-7-酮的結晶游離鹼、包含該游離鹼之藥學組成物及劑型、以及製造及使用此等化合物、組成物及劑型於治療細胞增生疾病(諸如癌症)之方法。
