MONOHIDRATO CRISTALINO DE 3-{(S)-1-[4-(1-CICLOPROPIL-2-OXO-1,2-DIHIDROPIRIDIN-4-IL)FENIL]ETIL}-(S)-6-(2-HIDROXI-2-METILPROPIL)-6-FENIL-[1,3]OXAZINAN-2-ONA
Refers to a hydrate of the compound derived from oxazinan - 2 - ona formula (IP3) and (IP1) where G1 is alkyl (c1-c4), (c1-c4) alkoxy, halogen, among others G2A is alkyl (c1-c4) haloalquilo (C1, C2, C3 (cycloalkyl) - C4), among others, G2B is H, Methyl or Ethyl methyl or Ethyl r1 R2 is phenyl or flu Orofenilo R3 is 2 - hydroxy - 2-methylpropyl or 2 - cyano - 2-methylpropyl n is 0 to 2.Preferred compounds are: (S) - 3 - ((S) - 1 - (4 - (1 - 2-cyclopropyl-1 - 2 - oxo - 1.2 - dihidropiridin - 4-yl) phenyl) ethyl) - 6 - (2-fluorophenyl) - 6 - (2 - hydroxy - 3 - (2-methylpropyl) oxazinan - 2 - One 2,2-dimethyl - 3 - ((R) - 3 - ((S) - 1 - (4 - (1 - methyl - 2 - oxo - 1.2 - dihidropiridin - 4-yl) phenyl) ethyl) - 2 - oxo - phenyl - 3 - 6 - 6 oxazinan - il) propanenitrile ent Re. It also relates to a Pharmaceutical composition.These compounds are inhibitors of 11b hydroxysteroid dehydrogenase Type 1 (11b HSD1) being useful in the treatment of DiabetesSE REFIERE A UN HIDRATO DEL COMPUESTO DERIVADO DE OXAZINAN-2-ONA DE FORMULA (Ip3) Y (Ip1) DONDE G1 ES ALQUILO(C1-C4), ALCOXI(C1-C4), HALOGENO, ENTRE OTROS G2a ES ALQUILO(C1-C4), HALOALQUILO(C1-C2), CICLOALQUILO(C3-C4), ENTRE OTROS G2b ES H, METILO O ETILO R1 ES METILO O ETILO R2 ES FENILO O FLUOROFENILO R3 ES 2-HIDROXI-2-METILPROPILO O 2-CIANO-2-METILPROPILO n ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: (S)-3-((S)-1-(4-(1-CICLOPROPIL-2-OXO-1,2-DIHIDROPIRIDIN-4-IL)FENIL)ETIL)-6-(2-FLUOROFENIL)-6-(2-HIDROXI-2-METILPROPIL)-1,3-OXAZINAN-2-ONA 2,2-DIMETIL-3-((R)-3-((S)-1-(4-(1-METIL-2-OXO-1,2-DIHIDROPIRIDIN-4-IL)FENIL)ETIL)-2-OXO-6-FENIL-1,3-OXAZINAN-6-IL)PROPANONITRILO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE 11B-HIDROXIESTEROIDE DESHIDROGENASA DE TIPO 1 (11B-HSD1) SIENDO UTILES EN EL TRATAMIENTO DE DIABETES
