SATO, Aaron Ken,GURNEY, Austin L.,HTUN VAN DER HORST, Edward Thein,LIU, Yuan Ching,BRUHNS, Maureen Fitch,HOEY, Timothy Charles,LEWICKI, John A.
申请号：
AU2016216568
公开号：
AU2016216568A1
申请日:
2016.08.16
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016216568A120160901.pdf#####ABSTRACT NOTCH-BINDING AGENTS AND ANTAGONISTS AND METHODS OF USE THEREOF The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
