Lewicki, John A.,Liu, Yuan Ching,Hoey, Timothy Charles,Bruhns, Maureen Fitch,Htun Van Der Horst, Edward Thein,Sato, Aaron Ken,Gurney, Austin L.
申请号：
AU2009269095
公开号：
AU2009269095B2
申请日:
2009.07.08
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-hgand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-hgand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
