GURNEY, AUSTIN, L,HOEY, TIMOTHY, CHARLES,HTUN VAN DER HORST, EDWARD, THEIN,SATO, AARON, KEN,LIU, YUAN, CHING,BRUHNS, MAUREEN, FITCH,LEWICKI, JOHN, A
申请号：
NZ59013109
公开号：
NZ590131A
申请日:
2009.07.08
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-hgand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-hgand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
