Maureen Fitch Bruhns;John A. Lewicki;Timothy Charles Hoey;Aaron Ken Sato;Yuan Ching Liu;Edward Thein Htun van der Horst;Austin L. Gurney
发明人:
Austin L. Gurney,Timothy Charles Hoey,Edward Thein Htun van der Horst,Aaron Ken Sato,Yuan Ching Liu,Maureen Fitch Bruhns,John A. Lewicki
申请号：
US12499627
公开号：
US08226943B2
申请日:
2009.07.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
