Austin L. GURNEY,Timothy Charles HOEY,Edward Thein Htun van der HORST,Aaron Ken SATO,Yuan Ching LIU,Maureen Fitch BRUHNS,John A. LEWICKI
申请号：
US15298527
公开号：
US20170198031A1
申请日:
2016.10.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
