GURNEY, AUSTIN L.,HOEY, TIMOTHY CHARLES,HTUN VAN DER HORST, EDWARD THEIN,SATO, AARON KEN,LIU, YUAN CHING,BRUHNS, MAUREEN FITCH,LEWICKI, JOHN A.
申请号：
MYPI 2011000058
公开号：
MY155603A
申请日:
2009.07.08
申请国别(地区):
MY
年份:
2015
代理人:
摘要：
THE PRESENT INVENTION RELATES TO NOTCH-BINDING AGENTS AND NOTCH ANTAGONISTS AND METHODS OF USING THE AGENTS AND/OR ANTAGONISTS FOR TREATING DISEASES SUCH AS CANCER. THE PRESENT INVENTION PROVIDES ANTIBODIES THAT SPECIFICALLY BIND TO A NON-LIGAND BINDING REGION OF THE EXTRACELLULAR DOMAIN OF ONE OR MORE HUMAN NOTCH RECEPTOR, SUCH AS NOTCH2 AND/OR NOTCH3, AND INHIBIT TUMOR GROWTH. THE PRESENT INVENTION FURTHER PROVIDES METHODS OF TREATING CANCER, THE METHODS COMPRISING ADMINISTERING A THERAPEUTICALLY EFFECTIVE AMOUNT OF AN ANTIBODY THAT SPECIFICALLY BINDS TO A NON-LIGAND BINDING REGION OF THE EXTRACELLULAR DOMAIN OF A HUMAN NOTCH RECEPTOR PROTEIN AND INHIBITS TUMOR GROWTH.
