A compound of Formula I: ** Formula ** or an N-oxide thereof or a pharmaceutically acceptable salt of said compound or said N-oxide, wherein: X1 is O or S； Y1 is O, S or NRN； Q1 is a 5-10 membered heterocycloalkyl containing N, a 5-10 membered heteroaryl containing N, or phenyl, wherein the heterocycloalkyl or heteroaryl is optionally substituted with 1, 2, 3, 4 or R7 independently selected ； and the phenyl is optionally substituted with 1, 2, 3, 4 or 5 R7a independently selected； each of RT1 and RT2 is independently selected from the group consisting of H, C1-3 alkyl, C1-3 fluoroalkyl, cyclopropyl, fluorocyclopropyl, C1-3 alkoxy, C1-3 haloalkoxy, -C (>； = O) -O - (C1-3 alkyl) and -C (>； = O) OH； R1 is selected from the group consisting of H, F, -C (>； = O) OH, -C (>； = O) -O- (C1-3 alkyl), C1-3 alkyl, C1-3 fluoroalkyl, cycloalkyl C3-6 and C3-6 fluorocycloalkyl, wherein said C3-6 cycloalkyl is optionally substituted with 1, 2, 3, 4 or 5 substituents each independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1 alkoxy -4 and C1-4 haloalkoxy； R2 is selected from the group consisting of H, halogen, -CN, -OH, C (>； = O) OH, -C (>； = O) -O- (C1-3 alkyl), C1-3 alkoxy, haloalkoxy C1-3, -N (R8) (R9), C1-3 alkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C2-6 alkenyl and C2-6 alkynyl, wherein said C3- cycloalkyl 6 is optionally substituted with 1, 2, 3, 4 or 5 substituents each independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy and C1-4 haloalkoxy； each of R3 and R4 is independently selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, -CN, C3-6 cycloalkyl, -C (>； = O) OH, C (>； = O) -O- (C1-4 alkyl) and halogen, wherein each of said C1-6 alkyl and C3-6 cycloalkyl are optionally substituted with 1, 2, 3, 4 or 5 substituents each independently selected from halo, -OH, -CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy and C1-4 haloalkoxy； each of R5 and R6 is independently se
