DAVOREN, Jennifer E.,DOUNAY, Amy Beth,EFREMOV, Ivan V.,GRAY, David L. F.,MENTE, Scot R.,O'NEIL, Steven V.,ROGERS, Bruce N.,SUBRAMANYAM, Chakrapani,ZHANG, Lei
申请号：
ES13820925
公开号：
ES2652514T3
申请日:
2013.10.30
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula I: ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein: X1 is N or CT4； Q1 is a 5-6 membered heteroaryl containing N or a 5-6 membered heterocycloalkyl containing N, each optionally substituted with an R9 and more optionally substituted with 1, 2, 3 or 4 R10； T2 is H； T3 is H； each of T1 and T4 is independently selected from the group consisting of H, F, -CN, methoxy, C1 fluoroalkoxy, methyl and C1 fluoroalkyl； each of R1 and R2 is independently selected from the group consisting of H, halogen, -CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C3-6 cycloalkyl, -C (>； = O) OH, and C (>； = O) -O- (C1-4 alkyl), wherein each of said C1-6 alkyl and C3-6 cycloalkyl are optionally substituted with 1, 2, 3, 4 or 5 substituents each independently selected from halo, -OH, -CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy and C1-4 haloalkoxy； each of R3 and R4 is independently selected from the group consisting of H, halogen, -OH, -NO2, -CN, -SF5, C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkoxy, C2 alkenyl 6, C2-6 alkynyl, C3-7 cycloalkyl, a 4-10 membered heterocycloalkyl, -N (R5) (R6), -N (R7) (C (>； = O) R8), -C (>； = O ) - N (R5) (R6), -C (>； = O) -R8, -C (>； = O) -OR8, -N (R7) (S (>； = O) 2R8), -S (>； = O) 2-N (R5) (R6), -SR8 and -OR8, wherein each of said C1-6 alkyl, C3-7 cycloalkyl and heterocycloalkyl are optionally substituted with 1, 2 or 3 substituents each independently selected from the group consisting of halogen, -CN, -OH, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C3-6 cycloalkyl, -N (R5) (R6), - N (R7) (C (>； = O) R8), -C (>； = O) -OR8, -C (>； = O) H, - C (>； = O) R8, -C (>； = O) N (R5) (R6), -N (R7) (S (>； = O) 2R8), -S (>； = O) 2-N (R5) (R6), -SR8 and -OR8； R5 is H, C1-4 alkyl, C1-4 haloalkyl or C3-7 cycloalkyl； ...Un compuesto de Fórmula I: **(Ver fórmula)** o una sal farmacéuticamente aceptable del mismo, en la que: X1 es N o CT4； Q1 es un heteroarilo de 5 a 6 miem
