Provided herein are triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.本文提供基於三氮雜環十二烷磺醯胺(“TCD”)之蛋白分泌抑制劑(諸如Sec61抑制劑)、其製備方法、相關醫藥組成物及使用其之方法。例如，本文提供式(I)化合物：及包含其之醫藥學上可接受的鹽及組成物。本文所揭露之化合物可用於(例如)治療包含發炎及/或癌症之疾病。
