KELLY III, MICHAEL J.,麦可J 凯利三世,麥可J 凱利三世,LAYTON, MARK E.,马克E 莱顿,馬克E 萊頓,SANDERSON, PHILIP E.,菲力普E 桑德逊,菲力普E 桑德遜,麦可J 凯利三世,麥可J 凱利三世,马克E 莱顿,馬克E 萊頓,菲力普E 桑德逊,菲力普E 桑德遜
申请号:
TW096145487
公开号:
TWI386410B
申请日:
2007.11.29
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.本發明提供抑制Akt活性之經取代啶化合物。詳言之,所揭示之該等化合物選擇性抑制Akt同功異型物之一或兩者。本發明亦提供包含該等抑制性化合物之組合物及藉由向需要治療癌症之患者投與該化合物來抑制Akt活性之方法。