Provided are compounds of formular (I), which can inhibit glutaminase. Pharmaceutial compositions comprising these compounds and uses as glutaminase inhibitors for treaing cancers thereof are also provided.在此描述了抑制麩醯胺酸酶之化合物以及包含這些化合物之組合物。在此還描述了在癌症治療中使用這些抑制麩醯胺酸酶的化合物之方法。