Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington’s disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.本發明提供特定化合物及其醫藥學上可接受之鹽。本發明還提供醫藥組成物，其包含至少一種化合物或其醫藥學上可接受之鹽，和一種或多種醫藥學上可接受之載劑。本發明描述了治療患有對抑制轉麩醯胺酸酶TG2活性有反應的特定疾病狀態的病患的方法。這些疾病狀態包括神經變性障礙例如亨廷頓病。本發明還描述了治療方法，其包括將至少一種化合物或其醫藥學上可接受之鹽作為單一活性劑投藥，或將至少一種化合物或其醫藥學上可接受之鹽與一種或多種其它治療劑組合投藥。
