化合物农业专利-农业专业知识服务系统

发明人:: BELL, ANDREW SIMON,贝尔　安卓　赛门,貝爾　安卓　賽門,BROWN, ALAN DANIEL,布朗　艾伦　丹尼尔,布朗　艾倫　丹尼爾,DE GROOT, MARCEL JOHN,德　葛鲁特　马歇尔　约翰,德　葛魯特　馬歇爾　約翰,LEWTHWAITE, RUSSELL ANDREW,路斯伟特　罗素　安德鲁,路斯偉特　羅素　安德魯,MARSH, IAN ROGER,马许　伊恩　罗杰,贝尔安卓赛门,貝爾安卓賽門,布朗艾伦丹尼尔,布朗艾倫丹尼爾,德葛鲁特马歇尔约翰,德葛魯特馬歇爾約翰,路斯伟特罗素安德鲁,路斯偉特羅素安德魯,马许伊恩罗杰

摘要：: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I):or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.本發明係關於磺醯胺衍生物、其在醫學之用途、含有其之組合物、其製備方法及用於該等方法之中間物。本發明更特別關於式(I)之新穎磺醯胺Nav1.7抑制劑：或其醫藥學上可接受之鹽，其中Ar1、X、R1、R2、R3、R4及R5如說明書中所定義。Nav1.7抑制劑可適用於治療廣泛範圍之病症，尤其疼痛。