Zhiwei Wang;Glen Spraggon;Hank Michael James Petrassi;Agnes Vidal;Badry Bursulaya;David C. Tully;Amab K. Chatterjee
发明人:
David C. Tully,Amab K. Chatterjee,Agnes Vidal,Hank Michael James Petrassi,Zhiwei Wang,Badry Bursulaya,Glen Spraggon
申请号：
US13089973
公开号：
US08338469B2
申请日:
2011.04.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
