The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.本發明提供結合於人類TIGIT(具有Ig及ITIM結構域之T細胞免疫受體)之抗體或其抗原結合片段，以及此等抗體或片段用於治療應用，諸如治療癌症或慢性病毒感染之用途。此類治療方法包括與諸如PD-1/PD-L1相互作用之其他免疫調節受體相互作用之抑制劑的組合療法。本發明進一步提供編碼抗體之重鏈及/或輕鏈可變區的聚核苷酸、包含編碼抗體之重鏈及/或輕鏈可變區之聚核苷酸的表現載體、包含該等載體之細胞及藉由自該等細胞表現抗體或片段來製備抗體或片段之方法。
