The present invention includes antibodies and antigen-binding fragments thereof that specifically bind to human or cynomolgous monkey LAG3 as well as immunoglobulin chains thereof and polynucleotides encoding the same along with injection devices comprising such antibodies or fragments. Vaccines including such antibodies and fragments as well as compositions comprising the antibodies and fragments (e.g., including anti-PD1 antibodies) are included in the invention. Methods for treating or preventing cancer or infection using such compositions are also provided. In addition, methods for recombinant expression of the antibodies and fragments are part of the present invention.本發明包括特異性結合於人類或獼猴(cynomolgous monkey)LAG3以及其免疫球蛋白鏈之抗體及其抗原結合片段,及編碼該等抗體及其抗原結合片段之聚核苷酸,以及包含此類抗體或片段之注射裝置。包括此類抗體及片段之疫苗以及包含該等抗體及片段(例如包括抗PD1抗體)之組合物亦包括於本發明中。亦提供使用此類組合物治療或預防癌症或感染之方法。此外,用於抗體及片段之重組型表現之方法為本發明之一部分。
