The present invention provides people PD-1 antibody, its antigen-binding fragment and its medical usages. Additionally provide the purposes of chimeric antibody, humanized antibody, the pharmaceutical composition comprising people PD-1 antibody and its antigen-binding fragment and the antibody comprising the antibody CDR region in the drug that preparation what treats disease or illness.本發明提供了人PD‑1抗體、其抗原結合片段及其醫藥用途。還提供了包含所述抗體CDR區的嵌合抗體、人源化抗體、包含人PD‑1抗體及其抗原結合片段的藥物組合物,以及所述抗體在製備用於治療疾病或病症的藥物中的用途。